Fig. 10 | Signal Transduction and Targeted Therapy

Fig. 10

From: Bile acid metabolism and signaling in health and disease: molecular mechanisms and therapeutic targets

Fig. 10

Hepatic FXR signaling—amino acid metabolism. Hepatic FXR signaling pertaining to nitrogen and protein metabolism. Hepatic FXR agonism increases urea cycle flux, glutamate shunting, and increases cap-dependent translation. Dashed mechanism arrows represent the Ras-Raf-MEK signaling cascade, while dashed arrows through a protein represent the direction of substrate flux. Proteins with a yellow outline represent kinases and phosphatases, while yellow arrows represent phosphorylation/dephosphorylation. Yellow P’s represent phosphate groups. Italicized text refers to genes while normal text refers to proteins. Question marks represent unknown mechanisms. This figure was created with BioRender.com

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