Fig. 16 | Signal Transduction and Targeted Therapy

Fig. 16

From: Bile acid metabolism and signaling in health and disease: molecular mechanisms and therapeutic targets

Fig. 16

BA-centric pathogenic mechanisms for IBD, cancer, and antiviral innate immune overactivity. a Novel BA metabolites enhance pTreg differentiation and inhibit Th17 differentiation, reducing autoimmune IBD-associated inflammation and enhancing gut-liver axis homeostasis. b The FGF15/19-[FGFR4/βk] axis can predispose for neoplastic promotion by inducing mitogenesis. In addition, the FGF15/19-[FGFR4/βk] axis can predispose for chemotherapeutic resistance by preventing chemotherapy-associated ferroptosis. c The Type 1 Interferon response induces TGR5-mediated activation of the cGAS-STING signaling cascade, enhancing antiviral responses, and potentially enhancing cGAS-STING-associated inflammation. Gold border proteins represent kinases, while gold arrows represent phosphorylation. mt is an abbreviation for “mitochondrial”. This figure was created with BioRender.com

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