Fig. 17 | Signal Transduction and Targeted Therapy

Fig. 17

From: Bile acid metabolism and signaling in health and disease: molecular mechanisms and therapeutic targets

Fig. 17

Structures of key FXR and TGR5 modulators. Red circles are drawn around the following key structural motifs: non-steroidal FXR agonist isoxazole pharmacophore, the acrylic acid motif of fexaramine likely to provide gut-selectivity, various kinetophores allowing for TGR5 gut-selectivity, and an example of a metabolic soft spot again providing gut-selective TGR5 agonism. This figure was created with BioRender.com

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