Fig. 3 | Signal Transduction and Targeted Therapy

Fig. 3

From: Bile acid metabolism and signaling in health and disease: molecular mechanisms and therapeutic targets

Fig. 3

Structural, physiochemical, and pharmacological properties of BAs: Representation of the structural scaffold, conjugates, physiochemical properties, and ranking of endogenous agonist pharmacology at the canonical BA receptors. Sites R1 through R6 represent locations for enzymatic hydroxylation. α-orientation groups are located beneath the steroidal plane, while β-orientation hydroxyl groups are located above the steroidal plane. Subscripted values next to BA names represent the species of origin: (H = Human), (R = Rodent), (Ht = Human Traces), (Rt = Rodent Traces). This figure was created with BioRender.com

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