Table 1 Interspecies variation in BA pool composition: human vs. mice
Human liver (%) (n = 10)723 | Mice liver (%) (n = 20)724 | Human feces (%) (n = 97)725 | Mice colon (%) (n = 8)726 | Mice ileum (%) (n = 11–12)727 | Human serum (%) (n = 56)511 | Mice serum (%) (n = 9)724 | Human plasma (%) (n = 18)724 | Mice plasma (%) (n = 6)724 | Human adipose tissue (%) (n = 24)726 | Mice gallbladder (%) (n = 8)726 | |
|---|---|---|---|---|---|---|---|---|---|---|---|
Primary BAs | |||||||||||
CA | Not Measured | 0.3 | 5.16 | 6.12 | 7.39 | 7.18 | 0.7 | 3.85 | 2.45 | 0 | 1.16 |
[G]CA | Not Measured | 0.21 | 18.32 | 0.12 | Not Measured | 7.53 | 0.2 | 7.27 | 0.13 | 8.83 | 0.18 |
[T]CA | Not Measured | 36.85 | 0.38 | 8.31 | 7.53 | 1.78 | 39.4 | 1.99 | 41.26 | 14.72 | 42.63 |
CDCA | Not Measured | 0.02 | 2.72 | 0.44 | 0.23 | 14.08 | 0.04 | 8.98 | 0.2 | 0 | 0.01 |
[G]CDCA | Not Measured | 0 | Not Measured | 0.18 | Not Measured | 23.28 | 0.01 | 32.2 | 0.03 | 18.73 | 0.02 |
[T]CDCA | Not Measured | 1.66 | 0.31 | 0.42 | 0.18 | 3.43 | 2.69 | 7.12 | 1.52 | 3.06 | 0.68 |
HCA/γMCA | Not Measured | 0 | 0.62 | 0.16 | Not Measured | 0 | 0 | 0 | 0 | 0 | 0 |
[G]HCA | Not Measured | Not Measured | Not Measured | 0 | Not Measured | Not Measured | Not Measured | Not Measured | Not Measured | 0 | 0 |
[T]HCA | Not Measured | 0 | Not Measured | 0.23 | Not Measured | Not Measured | Not Measured | Not Measured | Not Measured | 0 | 0.3 |
αMCA | Not Measured | 0.11 | Not Measured | 0.38 | 0.97 | 0 | 0.13 | 0 | 0.2 | 0 | 0.04 |
[T]αMCA | Not Measured | 7.86 | Not Measured | 3.06 | 4.27 | Not Measured | 11.07 | 0 | 7.84 | 0 | 9.79 |
βMCA | Not Measured | 1.27 | Not Measured | 1.46 | 3.69 | 0 | 0.69 | 0 | 2.09 | 0 | 0.08 |
[T]βMCA | Not Measured | 32.59 | Not Measured | 8.95 | 18.67 | Not Measured | 24.18 | 0 | 29.91 | 5.65 | 20.46 |
Secondary BAs | |||||||||||
DCA | Not Measured | 0.02 | 0 | 32.29 | 0.21 | 17.53 | 0.54 | 12.97 | 0.96 | 11.07 | 0.01 |
[G]DCA | Not Measured | 0 | 10.15 | 0.11 | Not Measured | 10.38 | 0 | 10.12 | 0 | 17.55 | 0.01 |
[T]DCA | Not Measured | 1.78 | 0.44 | 4.89 | 0.15 | 1.53 | 2.05 | 2.71 | 1.84 | 4.95 | 1.43 |
LCA | Not Measured | 0 | 50.43 | 2.01 | 0 | 0.78 | 0 | 0 | 0 | 0 | 0.01 |
[G]LCA | Not Measured | 0 | 0.02 | 0.3 | Not Measured | 0.63 | 0 | 1.28 | 0 | 9.54 | 0.01 |
[T]LCA | Not Measured | 0.11 | 0.09 | 0.24 | 0 | Not Measured | 0.04 | 0.13 | 0.09 | 0 | 0.15 |
UDCA | Not Measured | 0.01 | 0 | 0.59 | 0.27 | 3.68 | 0.02 | 0.14 | 0.66 | 0 | 0 |
[G]UDCA | Not Measured | 0 | 0.07 | 0.02 | Not Measured | 8.25 | 0.01 | 9.26 | 0.01 | 2.36 | 0.01 |
[T]UDCA | Not Measured | 2.75 | Not Measured | 0.45 | 0.73 | Not Measured | 3.24 | 0.85 | 2.22 | 0.94 | 4.21 |
HDCA | Not Measured | 0.01 | 8.32 | 10.41 | Not Measured | 0 | 0 | 0 | 0.33 | 0 | 0 |
[G]HDCA | Not Measured | Not Measured | 0.07 | 0.02 | Not Measured | 0 | Not Measured | Not Measured | Not Measured | 0.24 | 0.01 |
[T]HDCA | Not Measured | 0.01 | Not Measured | 2.05 | Not Measured | Not Measured | Not Measured | Not Measured | Not Measured | 0 | 1.84 |
ωMCA | Not Measured | 0.21 | Not Measured | 1.23 | 2.92 | 0 | 0.51 | 0 | 0.67 | 0 | 0.04 |
[T]ωMCA | Not Measured | 13.52 | Not Measured | 14.16 | 52.78 | Not Measured | 13.09 | 0 | 6.54 | 2.36 | 16.56 |
Special BA Derivatives | |||||||||||
alloCA | Not Measured | 0.04 | Not Measured | Not Measured | Not Measured | Not Measured | 0.18 | 0 | 0.14 | Not Measured | Not Measured |
7-oxo-DCA | Not Measured | 0.11 | Not Measured | 0.96 | Not Measured | Not Measured | 0.54 | 0 | 0.51 | 0 | 0.35 |
alloDCA | Not Measured | 0 | Not Measured | Not Measured | Not Measured | Not Measured | 0.07 | 0.01 | 0.08 | Not Measured | Not Measured |
Allo-3β-DCA | Not Measured | 0 | Not Measured | Not Measured | Not Measured | Not Measured | 0 | 0.85 | 0 | Not Measured | Not Measured |
Allo-12β-DCA | Not Measured | 0 | Not Measured | Not Measured | Not Measured | Not Measured | 0 | 0 | 0 | Not Measured | Not Measured |
Allo-3β-LCA | Not Measured | 0 | Not Measured | Not Measured | Not Measured | Not Measured | 0 | 0 | 0 | Not Measured | Not Measured |
alloLCA | Not Measured | 0 | Not Measured | Not Measured | Not Measured | Not Measured | 0 | 0 | 0 | Not Measured | Not Measured |
3-oxo-LCA | Not Measured | 0 | Not Measured | Not Measured | Not Measured | Not Measured | 0 | 0 | 0 | Not Measured | Not Measured |
7-oxo-LCA | Not Measured | 0 | Not Measured | Not Measured | Not Measured | Not Measured | 0 | 0.07 | 0.06 | Not Measured | Not Measured |
[T]7-oxo-LCA | Not Measured | 0.53 | Not Measured | Not Measured | Not Measured | Not Measured | 0.59 | 0 | 0.29 | Not Measured | Not Measured |
12-oxo-LCA | Not Measured | 0 | Not Measured | 0.41 | Not Measured | Not Measured | 0.01 | 0.2 | 0 | 0 | 0 |
6,7-dioxo-LCA | Not Measured | 0.03 | Not Measured | 0 | Not Measured | Not Measured | 0 | 0 | 0 | Not Measured | Not Measured |
isoLCA | Not Measured | Not Measured | 2.9 | Not Measured | Not Measured | 0 | Not Measured | Not Measured | Not Measured | Not Measured | Not Measured |
7-oxo-HDCA | Not Measured | Not Measured | Not Measured | 0.02 | Not Measured | Not Measured | Not Measured | Not Measured | Not Measured | 0 | 0 |
Categorical Breakdown | |||||||||||
Total CA | 47.2 | 37.4 | 23.86 | 14.55 | 14.92 | 16.49 | 40.48 | 13.11 | 43.97 | 23.56 | 43.97 |
Total CDCA | 46.27 | 1.68 | 3.03 | 1.04 | 0.41 | 40.79 | 2.74 | 48.3 | 1.75 | 21.79 | 0.71 |
Total DCA | 3.11 | 1.91 | 10.59 | 38.24 | 0.36 | 29.44 | 3.19 | 26.65 | 3.39 | 33.57 | 1.8 |
Total LCA | 1.09 | 0.67 | 53.44 | 2.96 | 0 | 1.41 | 0.65 | 1.69 | 0.44 | 9.54 | 0.17 |
Total UDCA | 2.33 | 2.76 | 0.07 | 1.06 | 1 | 11.93 | 3.27 | 10.26 | 2.89 | 3.3 | 4.22 |
Total MCA | Not Measured | 55.58 | Not Measured | 42.13 | 83.3 | Not Measured | 49.67 | 0 | 47.58 | 8.25 | 49.12 |
Glycine Conjugates | Not Measured | 0.21 | 28.63 | 0.75 | 0 | 50.07 | 0.22 | 60.13 | 0.17 | 57.25 | 0.24 |
Taurine Conjugates | Not Measured | 97.87 | 19.54 | 42.88 | 84.31 | 14.27 | 96.55 | 20.07 | 91.64 | 40.51 | 98.23 |
Non-Conjugated | Not Measured | 1.92 | 51.83 | 56.37 | 15.69 | 35.66 | 3.23 | 19.8 | 8.19 | 2.24 | 1.53 |
