Fig. 5 | Signal Transduction and Targeted Therapy

Fig. 5

From: Cholangiocarcinoma combined with biliary obstruction: an exosomal circRNA signature for diagnosis and early recurrence monitoring

Fig. 5

Establishment and validation of diagnostic models. The abundance of hsa-circ-0000367, hsa-circ-0021647, and hsa-circ-0000288 in a bile and b serum exosomes were measured by qPCR in the training cohort. ROC curves of c bile and d serum circRNA signatures (Bile-DS and Serum-DS) were illustrated. e The diagnostic power of Bile-DS, Serum-DS and CA19-9 was compared. f Summary of the established diagnostic models and their verification in the validation cohort. Cutoff values were determined by optimal Youden’s index. g The abundance of circRNAs in bile exosomes and serum counterparts showed correlation with each other. h Patients in the training cohort were grouped by high/low diagnostic scores and compared of clinical outcomes. *P < 0.05; **P < 0.01; ***P < 0.001; \({{\rm{n}}.{\rm{s}}.\atop }{\rm{not}}\,{\rm{significant}}\); (Mann–Whitney U test for continuous variables, presented as median with range and quartile; Pearson’s chi-squared test for categorical variables)

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