Fig. 5 | Signal Transduction and Targeted Therapy

Fig. 5

From: 2-APQC, a small-molecule activator of Sirtuin-3 (SIRT3), alleviates myocardial hypertrophy and fibrosis by regulating mitochondrial homeostasis

Fig. 5

Transcriptomics-based identification of possible molecular mechanisms of HF improvement effect of 2-APQC in H9c2 cells. a, b The volcano plots showing the differential expression of genes in the heart tissues of CON VS ISO and ISO VS ISO + 2-APQC as shown. c, d Heat map analysis of genes differentially expressed in rat hearts of Con and ISO and ISO and ISO ISO + 2-APQC, grouping all related genes into hierarchical clusters. e, f GO analysis of genes differentially expressed in rat hearts of Con and ISO and ISO and ISO ISO + 2-APQC. g SIRT3-regulated PPI after 2-APQC treatment

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