Fig. 1 | Signal Transduction and Targeted Therapy

Fig. 1

From: Peripheral immune cell-derived matrix metalloprotease 8 (MMP8): brain trafficking promotes depression-like behavior

Fig. 1

MMP8 links social stress to depression-like behavior and presents a potential drug target. Experience of social stress leads to the expansion of peripheral monocytes including transcription and secretion of MMP8 into the blood flow. Monocytes and MMP8 traffic to the brain, where MMP8 penetrates the pre-damaged BBB in susceptible mice. MMP8 degrades components of the ECM, thus altering the ECS, and neuronal activity and ultimately promoting depression-like behavior. Created with BioRender.com, license agreement VF26OEUBPH

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