Fig. 3 | Signal Transduction and Targeted Therapy

Fig. 3

From: Enhanced potency of an IgM-like nanobody targeting conserved epitope in SARS-CoV-2 spike N-terminal domain

Fig. 3

The complex structure of N235 bound to the NTD. a The overall structure of N235/S2L20/BA.1-NTD complex. b Structural details of N235 (magenta) binding to BA.1-NTD (gray). The structure is shown as a cartoon and residues involved in the hydrophobic interaction as sticks. H-bonds are presented as yellow dotted lines. c Comparison of epitope footprints between N235 (magenta) and previously reported antibodies on the NTD surface: 4A8 (pink, PDB: 8dm4), CV3-13 (orange, PDB: 7rq6), PVI.V6-14 (cyan, PDB: 7rbu), S2L20 (green) and C1717 (blue, PDB: 7uar). Mutations occurring in previously circulating VOCs (Alpha, Beta, Gamma and Delta) and currently circulating Omicron sub-variants (BA.1, BA.2, BA.2.75, BA.2.3.20, BA.3, BA.4, BA.5, BA.5.1.3, BQ.1, BQ.1.1, BF.7, XBB, XBB.1.5, EG.5, EG.5.1, BA.2.86 and JN.1) are presented in yellow

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