Fig. 3 | Signal Transduction and Targeted Therapy

Fig. 3

From: Harnessing the potential of hydrogels for advanced therapeutic applications: current achievements and future directions

Fig. 3

Structural comparison of CAR-T and TCR-T. The CAR structure of CAR-T cell includes an outward-facing antigen recognition domain that identifies specific antigens on cancer cell surfaces, a transmembrane domain anchoring the CAR to the T cell membrane, a co-stimulatory domain (e.g., CD28 or 4-1BB) and an activation domain (typically the CD3ζ chain), both of which work together to transmit signals that activate the T cell. TCR-T cells comprise two distinct protein chains (α and β chains) that interact with peptide-MHC complexes across several regions. Activation of the TCR depends on the CD3 complex and additional costimulatory signals (e.g., CD28). Information is collected from published work.790,823,824 Adobe Illustrator was used to generate this figure

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