Table 3 Representative clinical trials of cell therapy with hydrogels
Scaffold Type | Cell type | Registration number | Disease/Conditions | Phase |
|---|---|---|---|---|
Fibrin hydrogel | AADSCs & MMSCs | NCT03113747 | Burn wounds | II |
Gelatin hydrogel | hCSCs | NCT00981006 | Refractory heart failure with chronic ischemic cardiomyopathy | I |
Biocomposite hydrogel | MSCs | NCT06028763 | Ankle cartilage lesions | Not applicable |
/ | MSCs | NCT04497805 | Diabetic foot ulcer | II |
Collagen hydrogel | ASCs | NCT04503161 | Skull base unclosure | Not applicable |
Gelatin based hydrogel | SRCs | NCT02525263 | Chronic kidney disease | II |
/ | hNTSCs & hNCs | NCT06051747 | Trachea regeneration | II |
Fibrin gel | hESCs | NCT02057900 | Ischemic heart disease | I |
Bovine collagen type I hydrogel | iPSC-CMs & stromal cells | NCT04396899 | Heart failure | II |
/ | MSCs | NCT01879046 | Osteoarthritis | Not applicable |
/ | MSCs | NCT02394873 | Second-degree burn wounds | I |
Collagen hydrogel | Chondrocytes | NCT04399239 | Pinna reconstruction | II |
Hyaluronic acid gel | MSCs | NCT01981330 | Vocal cord scarring | I |
/ | BMMCs & MSCs | NCT05631444 | Chronic limb-threatening ischemia | II |
Collagen gel | BMMCs & MSCs | NCT02648386 | Pelvic autonomic repair | II |
