Table 5 Summary of OVs under clinical investigation for the treatment of cancer

T-VEC (Talimogene Laherparepvec)

HSV-1

human GM-CSF

ICP34.5, ICP47

I/II/III

melanoma, breast cancer, sarcoma, head and neck, colorectal cancer

^{315,317,318,319}

G47Δ

HSV-1

α47

I/II

glioma

^20,324

CAN-3110

HSV-1

I

glioma

⁴⁷¹

OrienX010

HSV-1

human GM-CSF

I

melanoma

⁴⁷²

OH2

HSV-2

human GM-CSF

ICP34.5, ICP47

I/II

esophageal cancer, colorectal cancer, gastric cancer, melanoma, head and neck cancer, cholangiocarcinoma, ovarian cancer, breast cancer

³³⁶

DNX-2401 (tasadenoturev)

adenovirus

RGD motif

E1A

I/II

glioma

^321,322,473

CRAd-S-pk7

adenovirus

human survivin promoter

I

glioma

³³⁸

VCN-01

adenovirus

E2F1 promoter

E1A

I

retinoblastoma, pancreatic cancer

^334,474

Telomelysin (OBP-301)

adenovirus

human TERT promoter, IRES

I

liver cancer, esophageal cancer, head and neck cancer, lung cancer, neuroendocrine cancer, melanoma, leiomyosarcoma, sarcoma, basal cell carcinoma, salivary gland tumor, breast cancer

^475,476,477

ICOVIR-5

adenovirus

E2F1 promoter

E1A

I

melanoma, medulloblastoma, astrocytoma, neuroblastoma, thyroid cancer, thymoma, lung cancer, colorectal cancer, sarcoma

³³⁹

enadenotucirev

adenovirus

I

ovarian cancer, colorectal cancer, head and cancer, urothelial cancer, renal cancer, lung cancer

^478,479,480

ONCOS-102

adenovirus

human GM-CSF

E1A

I/II

pleural mesothelioma, ovarian cancer, colorectal cancer, liver cancer, endometrial cancer, sarcoma, breast cancer

³³⁰

MV-NIS

measles virus

human NIS

I

multiple myeloma

^481,482

MV-CEA

measles virus

human CEA

I/II

glioma, ovarian cancer

^483,484

V937 (CVA21)

coxsackievirus

I/II

melanoma, lung cancer, urothelial cancer, prostate cancer

^325,485,486

ParvOryx

parvovirus

I/II

pancreatic cancer, glioma

^487,488,489

PVSRIPO (Lerapolturev)

poliovirus

IRES

I

melanoma, glioma

^490,491,492

REOLYSIN (Pelareorep)

reovirus

I/II

esophageal cancer, prostate cancer, melanoma, pancreatic cancer, breast cancer, stomach cancer, lung cancer, liver cancer, mesothelioma, ovarian cancer, tubal cancer, peritoneal cancer, multiple myeloma

^{326,493,494,495,496,497}

NTX-010 (SVV-001)

Seneca Valley virus

I/II

small cell lung cancer, carcinoid tumor, adrenal cortical carcinoma, embryonal rhabdomyosarcoma, alveolar rhabdomyosarcoma, Wilms’ tumor, ganglioneuroblastoma, neuroblastoma

^329,498

JX-594 (Pexa-Vec)

vaccinia virus

human GM-CSF

thymidine kinase (TK)

I/II

sarcoma, liver cancer, melanoma, colorectal cancer, pancreatic cancer, bladder cancer

^{331,335,499,500}