Table 2 Approved nanomedicine for cancer
From: Current advance of nanotechnology in diagnosis and treatment for malignant tumors
Therapeutic type | Product name | Therapeutic agent | Nanocarrier | Administration route | Indications | First approval |
|---|---|---|---|---|---|---|
Chemotherapy | Doxil | Doxorubicin | PEGylated liposomes | iv. | Kaposi sarcoma, breast cancer, ovarian cancer, multiple myeloma | USA 1995 |
Chemotherapy | Caelyx | Doxorubicin | PEGylated liposome | iv. | Metastatic breast, Kaposi’s sarcoma, multiple myeloma | USA 1996 |
Chemotherapy | DaunoXome | Daunorubicin | Liposomes | iv. | Kaposi sarcoma | USA 1996 |
Chemotherapy | Myocet | Doxorubicin | Liposomes | iv. | Metastatic breast cancer | USA 1996 |
Chemotherapy | DepoCyt | Cytarabine | Liposomes | iv. | Lymphomatous meningitis | USA 1999 |
Chemotherapy | Eligard | Leuprolide | Polymeric micelles | iv. | Prostate cancer | USA 2002 |
Chemotherapy | Lipusu | Paclitaxel | Liposomes | iv. | Ovarian cancer, metastatic gastric cancer | China 2003 |
Chemotherapy | Oncaspar | Pegaspargase | Polymeric micelles | iv. | Acute lymphoblastic leukemia | USA 1994 |
Chemotherapy | MEPACT | Mifamurtide | Liposomes | iv. | Osteosarcoma | Europe 2009 |
Chemotherapy | Ameluz | 5-aminolevulinic acid | Liposomes | it. | Nodular basal cell carcinoma | USA 2011 |
Chemotherapy | Marqibo | Vincristine sulfate | Liposomes | iv. | Philadelphia chromosome-negative acute lymphoblastic leukemia | USA 2012 |
Chemotherapy | Lipodox | Doxorubicin hydrochloride | Liposome | iv. | Kaposi’s sarcoma, ovarian cancer, multiple myeloma, metastatic pancreatic cancer | Chnia 2013 |
Chemotherapy | Kadcyla | DM1(or Emtansine) | Protein | iv. | Breast cancer | USA 2013 |
Chemotherapy | Paclical | Paclitaxel | polymeric nanoparticle-based | iv. | Pancreatic cancer, metastatic breast cancer | USA 2015 |
Chemotherapy | Onivyde | Irinotecan | PEGylated liposomes | iv. | Metastatic pancreatic cancer | USA 2015 |
Chemotherapy | VYXEOS | Cytarabine/daunorubicin (5∶1) | Liposomes | iv. | Acute myeloid leukemia | USA 2017 |
Chemotherapy | Pazenir | Paclitaxel | Micelle | iv. | Metastatic breast cancer, metastatic pancreatic cancer, non-small cell lung cancer | USA 2019 |
Chemotherapy | Apealea | Paclitaxel | Nanocrystal | iv. | Ovarian cancer, peritoneal cancer, fallopian tube cancer | USA 2018 |
Chemotherapy | Abraxane | Paclitaxel | Albumin | iv. | Breast cancer, non-metastatic small cell lung cancer, metastatic adenocarcinoma of the pancreas | USA 2005 |
Chemotherapy | Ontak | Denileukin Diftitox | Protein | iv. | Cutaneous T-cell lymphoma | USA 1999 |
Chemotherapy | Genexol-PM | Paclitaxel | Polymeric micelles | iv. | Breast cancer, lung cancer | Korea 2007 |
Chemotherapy | Nanoxel | Paclitaxel | Polymeric micelles | iv. | Breast cancer, ovarian cancer | India 2007 |
Chemotherapy | Paclical | Paclitaxel | Polymeric micelles | iv. | Ovarian cancer | Russia 2015 |
Chemotherapy | PICN | Paclitaxel | Polymer/lipid NP | iv. | Metastatic breast cancer | India 2014 |
Chemotherapy | DHP107 | Paclitaxel | Lipid NP | po. | Advanced gastric cancer | Korea 2016 |
Chemotherapy | LipoplatinTM, NanoplatinTM | Cisplatin | Liposomes | iv. | Pancreatic cancer, lung cancer | USA 2018 |
Hyperthermia | NanoTherm | Fe2O3 | Metallic | iv. | Glioblastoma, prostate cancer, pancreatic cancer. | USA 2013 |
Hyperthermia | NanoTherm | — | Iron oxide NP | it. | Recurrent glioblastoma | Europe 2010 |
Radiotherapy enhancer | Hensify | — | Hafnium oxide NP | it. | Locally advanced soft tissue sarcoma | Europe 2019 |
