Fig. 1 | Signal Transduction and Targeted Therapy

Fig. 1

From: Dietary protein sources, gut microbiome, and puberty timing in children: findings from a cohort study

Fig. 1

Associations among dietary protein intake, the gut microbiome, and puberty timing in Chinese children. a Associations of protein-associated microbial and metabolic features with puberty timing comparing the highest tertiles with the lowest tertiles by Cox regression analyses. TPMI, total protein-microbial index; APMI, animal protein-microbial index; VPMI, vegetable protein-microbial index; HR, hazard ratio; CI, confidence interval. b Mediation analyses of protein-microbial indices in the associations between different sources of protein and pubertal development. ACME, average causal mediation effect. c Urine metabolites linked to the animal protein-microbial index (left panel) or vegetable protein-microbial index (right panel) according to the partial correlation analysis. The x-axis shows the rho value, and the y-axis indicates the −log (base 10) of the FDR-corrected P value. APMI, animal protein-microbial index; VPMI, vegetable protein-microbial index. d The associations between urine metabolites and animal protein or vegetable protein consumption. An asterisk represents a significant association

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