Fig. 7
From: Targeting Lactobacillus johnsonii to reverse chronic kidney disease
Reduced serum IAld level correlated with renal function decline in CKD patients and rat models. a Associations between levels of eight tryptophan metabolites and eGFR in CKD patients. b Combined box-and-whisker and dot plot of levels of IAld and 5-methoxytryptophan in serum of Sham and NX rats. Mean values are presented by horizontal bars. The whiskers indicate the maximum and minimum points (n = 8/group). c The associations between creatinine levels and IAld and 5-methoxytryptophan levels in NX rats. d Combined box-and-whisker and dot plot of levels of IAld and 5-methoxytryptophan in serum of Sham and UUO rats. Mean values are presented by horizontal bars. The whiskers indicate the maximum and minimum points. *P < 0.05, **P < 0.01 compared with Sham rats (n = 8/group). e The associations between tubulointerstitial damage score and IAld and 5-methoxytryptophan levels in UUO rats. f Relative levels of IAld and 5-methoxytryptophan in feces of control and CRF rats (n = 8/group). g Relative levels of IAld and 5-methoxytryptophan in feces of Sham and NX rats (n = 8/group). h Relative levels of IAld and 5-methoxytryptophan in feces of Sham and UUO rats (n = 8/group). i Relative levels of IAld and 5-methoxytryptophan in feces of healthy controls and CKD patients (n = 8/group). Data are represented as mean ± SEM
