Fig. 3
From: Signaling pathways involved in colorectal cancer: pathogenesis and targeted therapy
Comprehensive schematic depicting the genetic architecture and heritability of colorectal cancer. This schematic illustrates the genetic factors involved in familial and sporadic colorectal cancer. It categorizes genes based on their association with specific signaling pathways: Wnt signaling pathway (blue), MAPK signaling pathway (green), DNA repair/fidelity of DNA replication (red), and TGF-β/BMP signaling pathway (purple). Familial cases include genes like APC-FAP, MSH6/MLH6, and SMAD2, while sporadic cases involve genes such as ATF1, SMAD7, and TPD52L3. This visual aids in understanding the complex genetic landscape contributing to colorectal cancer
