Fig. 7
From: Characterization of ACTN4 as a novel antiviral target against SARS-CoV-2
The model of intricate interplay between host factor ACTN4 and SARS-CoV-2. (Left half part) SARS-CoV-2 infection decreases the m6A related factors and global m6A modification levels in cells, which correlates with reduction of ACTN4 expression. (Right half part) ACTN4 targets viral protein nsp12 for binding to block the viral RdRp complex formation, which causes inhibition of SARS-CoV-2 replication. Two ACTN4 agonists, YS-49 and demethyl-coclaurine, are identified to inhibit viral replication. This graphic model was created using the software of Photoshop
