Fig. 7
From: Cold and hot tumors: from molecular mechanisms to targeted therapy
Illustrates the tumor stroma cells and non-cellular components influencing the tumor microenvironment. The tumor comprises cancer cells and an encompassing stroma, which is a key constituent of the tumor microenvironment (TME), displaying distinct characteristics specific to the tumor type. This encompasses the extracellular matrix, a unique cancer-related vasculature, and various cellular elements such as activated cancer-associated fibroblasts, mesenchymal stromal cells, and pericytes. The cellular and non-cellular components within the tumor stroma actively engage in interdependent interactions, playing crucial roles in a finely regulated dynamic process. This collaborative mechanism promotes the evolution, progression, dissemination, and resistance to treatment of cancer. Notably, these findings underscore the integration of stromal-based cancer therapies in discourse. A profound comprehension of the dynamic interplay between stroma and cancer cells is imperative for devising innovative therapeutic approaches. In this context, black arrows represent promotion, while black bars symbolize inhibition. This figure was created using Figdraw
