Fig. 9 | Signal Transduction and Targeted Therapy

Fig. 9

From: Human adipose and umbilical cord mesenchymal stem cell-derived extracellular vesicles mitigate photoaging via TIMP1/Notch1

Fig. 9

Schematic illustrations of AMSC-EV and HUMSC-EV repairments on photoaging in vitro and in vivo via regulation of the TIMP1/Notch pathway (Created with BioRender.com). AMSC-EV and HUMSC-EV improve photoaging in UVB-irradiated nude mice, HaCaTs, HKCs, HDFs, and T-Skin models through anti-inflammatory effects, ECM remodeling, and anti-senescence properties. Mechanistically, proteomic analysis revealed that TIMP1 is highly expressed in both AMSC-EV and HUMSC-EV and exerts similar effects to MSC-EV. TIMP1 inhibits MMPs, thereby altering extracellular matrix remodeling. Additionally, TIMP1 downregulates the activated Notch pathway and inhibits its downstream targets Hes1, P16, P21, and P53

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