Fig. 2
From: Targeted protein degradation: advances in drug discovery and clinical practice
Schematic overview of TPD modalities. The left panel displays the ubiquitin-proteasome system and a protein not specifically targeted by E3 ubiquitin ligases, remaining undegraded. The middle panel presents the structural configurations of molecular glues (MGs) and proteolysis-targeting chimeras (PROTACs). The right panel details the TPD process, illustrating the cyclic interaction of PROTACs with a target protein and an E3 ligase, as well as the role of MGs in facilitating protein–protein interactions between E3 ligases and target proteins, thereby enhancing their association. This culminates in the ubiquitination and proteasomal degradation of the target protein, after which those modulators molecules are recycled
