Fig. 5 | Signal Transduction and Targeted Therapy

Fig. 5

From: A protein vaccine of RBD integrated with immune evasion mutation shows broad protection against SARS-CoV-2

Fig. 5

Results of EG.5.1 variant challenge in Balb/c mice after immunization. a Schematic illustration of the timeline of BALB/c mice immunization and challenge with SARS-CoV-2 (created with BioRender.com). Mice that were not immunized were used as controls. The challenge experiment was performed 21 days after the third immunization. b Body weight changes after infection in each group (n = 10). c Viral gRNA levels in the lung at 5 days post-infection (dpi) in each group (n = 5). d Histogram of mouse lung pathology scores in each group (n = 5). e Histopathological examination of mice lung tissues. Scale bar, 100 μm. The data are expressed as means ± SD. Results of each group were compared with the control group in c and d. Statistical analysis was conducted using one-way ANOVA and Tukey’s multiple comparison test for bar graphs. ***P < 0.005. ns not significant

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