Fig. 6 | Signal Transduction and Targeted Therapy

Fig. 6

From: A protein vaccine of RBD integrated with immune evasion mutation shows broad protection against SARS-CoV-2

Fig. 6

Results of EG.5.1 variant challenge in K18-hACE2 mice after immunization. a Schematic illustration of the timeline of BALB/c mice immunization and challenge with SARS-CoV-2 (created with BioRender.com). b Changes in survival rate of mice in each group within 5 days of infection. c Body weight changes after infection in each group (n = 3). d Viral gRNA levels in the lung at 5 dpi in each group (n = 3). e Histogram of mouse lung pathology scores in each group (n = 3). f Histopathological examination of mice lung tissues. AddaS03 as adjuvant control. The data are expressed as means ± SD. Results of each group were compared with the AddaS03 group in d and e. Statistical analysis was conducted using one-way ANOVA and Tukey’s multiple comparison test for bar graphs. *P < 0.05, **P < 0.01, ***P < 0.005

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