Fig. 1 | Signal Transduction and Targeted Therapy

Fig. 1

From: 5-Formylcytosine: a new epigenetic player

Fig. 1

Active demethylation of 5mC by TET dioxygenases and local enrichment of 5fC. a 5-Formylcytosine (5fC) acts as epigenetic player specifically recruiting and activating RNA Pol III transcription during ZGA. Note, ZGA occurs at species-specific time points, in mouse embryos at late one-cell stage, in Xenopus at mid-blastula. b Default model of TET dioxygenase/TDG-catalyzed demethylation of 5mC. However, high-resolution liquid chromatography-tandem mass spectrometry data from Xenopus embryos revealed a biphasic profile of 5fC independent of 5mC and 5hmC, and immunohistology indicated specific enrichment of 5fC at chromocenters and active tRNA repeats,1 suggesting a specific pathway of 5fC generation or local stabilization

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