Table 6 Liquid biopsy in digestive system cancers
From: Liquid biopsy in cancer: current status, challenges and future prospects
Cancer | Liquid biomarker | Origin | Tendency | Downstream target | Function | Reference |
|---|---|---|---|---|---|---|
HCC | miR-221-3p, miR-223-3p, miR-10b5p, miR-21-5p | Plasma exosome | up | Â | Early diagnostic biomarker | |
LG3BP, PIGR | Serum exosome | up | Â | Early diagnostic biomarker | ||
ECE1, HOXA1, cle11a, AK055957, PFKP, EMX1 methylation | Plasma | up | Â | Early diagnostic biomarker | ||
cfDNA | Plasma | up | Â | Early diagnostic biomarker, Efficacy monitoring biomarker | ||
CTCs | Peripheral blood | up | Â | Early diagnostic biomarker, Tumor recurrence biomarker | ||
Mixed CTCs, Mesenchymal CTCs | Peripheral blood | up | Â | Early diagnostic biomarker, Disease progression biomarker | ||
CCA | microRNA-21, microRNA-221 | Plasma | up | Â | Early diagnostic biomarker | |
hTERT, CK19 | Peripheral blood | up | Â | Prognostic biomarker | ||
Osteopontin (OPN) | Serum | down | MMP1, MMP10, CXCR4 | Efficacy monitoring biomarker, Prognostic biomarker | ||
MMP-7 | Serum | up | Â | Early diagnostic biomarker | ||
CYFRA 21-1 | Serum | up | Â | Early diagnostic biomarker, Disease progression biomarker | ||
Osteopontin (OPN) | Serum | up | Â | Efficacy monitoring biomarker | ||
CTCs | Peripheral blood | up | Â | Tumor aggressiveness biomarker, Prognostic biomarker | ||
cfDNA mutation | Bile | up | Â | Prognostic biomarker | ||
CRC | microRNA-203 | Serum exosome | up | M2-TAM | Prognostic biomarker | |
microRNA-21 | Plasma exosome | up | Â | Tumor recurrence biomarker, Prognostic biomarker | ||
miR-17-5p, miR-92a-3p | Serum exosome | up | Â | Early diagnostic biomarker, Disease progression biomarker | ||
miR-25-3p | Serum exosome | up | Â | Tumor aggressiveness biomarker | ||
miR-196b-5p | Serum exosome | up | STAT3 | Efficacy monitoring biomarker | ||
miR-301a, miR-23a | Serum exosome | UP | Â | Early diagnostic biomarker | ||
miR-19a | Serum exosome | up | Â | Tumor recurrence biomarker | ||
QSOX1 | Serum exosome | down | Â | Early diagnostic biomarker | ||
ctDNA | Plasma | up | Â | Efficacy monitoring biomarker | ||
ctDNA | Plasma | up | Â | Tumor recurrence biomarker, Prognostic biomarker |
