Fig. 1

Intratumor bacteria therapy remolds tumor physical and physiochemical microenvironment. a Schematic illustration of the bacterial therapy in adjuvating adoptive T cell therapy. E. coli elevates intratumor T cell-chemotaxis chemokines, normalizes tumor vasculature and remolds tumor microenvironments to promote T cells’ entry and killing efficiency. b The relative content of intratumor T cell-centered cytokine and chemokines in the control and E. coli-treated groups. Data are shown as mean ± s.e.m., n = 5–6 biologically independent samples. P values were determined by unpaired, two-tailed t-test. c Representative fluorescence staining of intratumor CD31, scale bar = 500 μm