Fig. 4 | Signal Transduction and Targeted Therapy

Fig. 4

From: CXCR1+ neutrophil infiltration orchestrates response to third-generation EGFR-TKI in EGFR mutant non-small-cell lung cancer

Fig. 4

CXCR1+ neutrophils exhibit immunosuppressive characteristics and play vital role in tumor microevironment. a Downregulated and upregulated pathway of CXCR1+ neutrophils. b The heatmap of hallmarker gene sets using GSVA. c Metabolism pathway activity of neutrophil subsets determined by scMetabolism. d Cell communications detected by CellChat analysis. e The outgoing and incoming interaction strength of each cell type. f The ligand-receptor pairs between CXCR1+ neutrophils and tumor cells. g Spatial analysis of CXCR1+ neutrophils between pretreatment and resistant samples

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