Table 1 Overview of CDKs-cyclin complexes and their main regulators
From: Cyclin-dependent protein kinases and cell cycle regulation in biology and disease
CDK | Cyclin/Cyclin-like | Main complex regulators | Regulators Effects on the CDK/cyclin complex |
|---|---|---|---|
CDK1 | Cyclin A1, A2 Cyclin B1, B2, B3 | CAK complex | Activating phosphorylation |
CDC24A, CDC25B, CDC25C | Activating de-phosphorylation | ||
WEE1, MYT1 | Inactivating phosphorylation | ||
p21Cip1/Waf1/Sdi1, p27Kip1 | Negative regulators | ||
CDK2 | Cyclin E1, E2, Cyclin A1, A2 | CAK complex | Activating phosphorylation |
CDC24A, CDC25B, CDC25C | Activating de-phosphorylation | ||
p21Cip1/Waf1/Sdi1, p27Kip1, p57Kip2 | Negative regulators | ||
CDK3 | Cyclin C | CAK complex | Activating phosphorylation |
p21Cip1/Waf1/Sdi1 | Negative regulator | ||
CDK4 | Cyclin D1, D2, D3 | CAK complex | Activating phosphorylation |
WEE1, MYT1 | Inactivating phosphorylation | ||
CDC25A | Activating de-phosphorylation | ||
p16INK4a, p15INK4b, p18INK4c, p19INK4d, p21Cip1/Waf1/Sdi1, p27Kip1 | Negative regulators | ||
CDK5 | p25/p35/p39 | CDK5RAP1 and 2 | Negative regulator |
CDK6 | Cyclin D1, D2, D3 | CAK complex | Activating phosphorylation |
WEE1, MYT1 | Inactivating phosphorylation | ||
CDC25A | Activating de-phosphorylation | ||
p16INK4a, p15INK4b, p18INK4c, p19INK4d, p21Cip1/Waf1/Sdi1, p27Kip1 | Negative regulators | ||
CDK7 | Cyclin H | MAT1 | Required for full CDK7 activation |
CDK8-Cyclin C | Inactivating phosphorylation | ||
CDK8 | Cyclin C | Med12-Med13 (and paralogs) | Required for full CDK8 activation |
p21Cip1/Waf1/Sdi1 | Stimulates CDK8 activity | ||
CDK9 | Cyclin T1, T2a, T2b Cyclin K | HEXIM1-2 7SK snRNA | Negative regulators |
BRD4 | Positive regulator | ||
CAK complex | Activating phosphorylation | ||
PP2A phosphatase | Activating de-phosphorylation | ||
p300 HAT | Acetylation of cyclin T1 (activation of P-TEFb complex) | ||
CDK10 | Cyclin M | - | - |
CDK11 | Cyclin L | - | - |
CDK12 | Cyclin K | CAK complex | Activating phosphorylation |
CDK13 | Cyclin K | CAK complex | Activating phosphorylation |
CDK14 | Cyclin Y Cyclin D3 | 14-3-3 | Increase of CDK14-Cyclin Y binding |
p21Cip1/Waf1/Sdi1 | Negative regulator | ||
CDK15 | - | - | - |
CDK16 | Cyclin Y Cyclin Y L1 | PKA | Increase of CDK16 kinase activity |
14-3-3 | Increase of CDK16 kinase activity | ||
CDK17 | - | - | - |
CDK18 | Cyclin A2 Cyclin E1 | PKA | Increase of CDK18 kinase activity |
CDK19 | Cyclin C | Med12-Med13 (and paralogs) | Required for full CDK19 activation |
CDK20 | Cyclin H | - | - |
