Table 2 The Role of CDKs in cancer

From: Cyclin-dependent protein kinases and cell cycle regulation in biology and disease

Tissue of origin

Oncogenic functions

Tumor-suppressive functions

Brain

CDK2-CDK3-CDK4-CDK6-CDK7-CDK14-CDK20

CDK10

Head & neck

CDK1-CDK3-CDK4-CDK7

 

Thyroid

CDK13

 

Lungs

CDK1-CDK2-CDK5-CDK7-CDK9-CDK20

CDK10

Breast

CDK1-CDK2-CDK4-CDK5-CDK6-CDK7-CDK8-CDK9-CDK11-CDK12-CDK13-CDK14-CDK19

CDK10-CDK12-CDK13

Liver

CDK1-CDK7-CDK9-CDK13-CDK14-CDK20

CDK10

Stomach

CDK2-CDK7-CDK8-CDK12-CDK14

CDK5-CDK8-CDK10-CDK12

Pancreas

CDK1-CDK5-CDK7-CDK8-CDK12-CD14

CDK8-CDK12

Colorectal

CDK1-CDK2-CDK3-CDK4-CDK7-CDK8-CDK10-CDK13-CDK19-CDK20

CKD8-CDK19

Reproductive and urinary system (female)

CDK1-CDK2-CDK7-CDK9-CDK11-CDK14-CDK20

CDK12-CDK13

Reproductive and urinary system (male)

CDK1-CDK2-CDK7-CDK8-CDK9-CDK12-CDK13-CDK14-CDK19

CDK8-CDK12-CDK13

Hematic and lymphatic circulation

CDK4-CDK6-CDK7-CDK8-CDK9-CDK11-CDK12-CDK13-CDK19

CDK8-CDK12-CDK13-CDK19

Bone and soft tissues

CDK2-CDK4-CDK6-CDK9-CDK11-CKD14

 

Skin

CDK1-CDK3-CDK4-CDK6-CDK8-CDK9-CDK12

CDK8-CDK12-CDK13

  1. Summary of the role of CDKs in cancer, categorized by the tissue of origin of the tumor and the oncogenic or tumor-suppressive functions of these kinases. CDKs have direct involvement in specific pathways and are often overexpressed or downregulated in tumors compared to healthy tissues. This table focuses exclusively on CDKs, excluding the various co-factors involved in their regulation. Detailed references related to the specific CDKs and their associations with different tumors are provided in the corresponding paragraph
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