Table 2 The Role of CDKs in cancer
From: Cyclin-dependent protein kinases and cell cycle regulation in biology and disease
Tissue of origin | Oncogenic functions | Tumor-suppressive functions |
---|---|---|
Brain | CDK2-CDK3-CDK4-CDK6-CDK7-CDK14-CDK20 | CDK10 |
Head & neck | CDK1-CDK3-CDK4-CDK7 | |
Thyroid | CDK13 | |
Lungs | CDK1-CDK2-CDK5-CDK7-CDK9-CDK20 | CDK10 |
Breast | CDK1-CDK2-CDK4-CDK5-CDK6-CDK7-CDK8-CDK9-CDK11-CDK12-CDK13-CDK14-CDK19 | CDK10-CDK12-CDK13 |
Liver | CDK1-CDK7-CDK9-CDK13-CDK14-CDK20 | CDK10 |
Stomach | CDK2-CDK7-CDK8-CDK12-CDK14 | CDK5-CDK8-CDK10-CDK12 |
Pancreas | CDK1-CDK5-CDK7-CDK8-CDK12-CD14 | CDK8-CDK12 |
Colorectal | CDK1-CDK2-CDK3-CDK4-CDK7-CDK8-CDK10-CDK13-CDK19-CDK20 | CKD8-CDK19 |
Reproductive and urinary system (female) | CDK1-CDK2-CDK7-CDK9-CDK11-CDK14-CDK20 | CDK12-CDK13 |
Reproductive and urinary system (male) | CDK1-CDK2-CDK7-CDK8-CDK9-CDK12-CDK13-CDK14-CDK19 | CDK8-CDK12-CDK13 |
Hematic and lymphatic circulation | CDK4-CDK6-CDK7-CDK8-CDK9-CDK11-CDK12-CDK13-CDK19 | CDK8-CDK12-CDK13-CDK19 |
Bone and soft tissues | CDK2-CDK4-CDK6-CDK9-CDK11-CKD14 | |
Skin | CDK1-CDK3-CDK4-CDK6-CDK8-CDK9-CDK12 | CDK8-CDK12-CDK13 |