Fig. 1
From: Chemical inducers of proximity: precision tools for apoptosis in transcriptional regulation
The transcription function of BCL6 relies on its binding with its co-expressors through its BTB domain. CDK-TCIPs bind to the BTB domain of BCL6, dissociate the co-expressors from BCL6, while at the same time recruit CDK9 to BCL6-bound DNA, resulting in the phosphorylation of RNA pol II, and consequently, expression of pro-apoptotic target genes. Created with BioRender.com
