Fig. 6 | Signal Transduction and Targeted Therapy

Fig. 6

From: Molecular principles underlying aggressive cancers

Fig. 6

Hallmarks of lung adenocarcinoma. Overexpression of active conformations such as catalytically primed kinases is associated with non-small cell lung cancer (NSCLC). These increased kinase activities are attributed to fusion genes, including NTRK fusion, AGK-BRAF fusion, EGFR-RAD51 fusion, EML4-ALK fusion, and RET fusion genes (see text for details). NSCLC also harbors HER2 alterations, MET overexpression, and K-Ras G12C mutation. Generic names of small drugs that inhibit these active molecules are shown in the figure with the brand name in parentheses

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