Fig. 1
From: Spatiotemporal transcriptomics elucidates the pathogenesis of fulminant viral myocarditis
The spatiotemporal landscape of FM mice. a Schematic diagram of the workflow for this study. b UMAP embedding of all the cells colored by manually annotated cell types. c Heatmap showing the expression levels of cell-typing genes in each cell type. The color represents the gene expression level. d Cell component changes among different time points. e Heatmap showing the expression levels of specific functional genes at different time points. The color represents the gene expression level. The spatial structures (f) and infection response score (g) of cardiac tissue sections from control and CVB3-infected mice from 1 to 7 dpi. Scale bar: 500 μm. h Spatial structure proportion changes among different time points. i Heatmap showing the Pearson correlation between cell types defined in snRNA-seq and spatial structures defined in stereo-seq data. j Spatial immune cell infiltration on cardiac tissue sections from CVB3-infected mice at 7 dpi. Scale bar: 500 μm for whole cardiac section, 100 μm for zoomed view. EC endothelial cell, Mac/mono macrophage/monocyte, FB fibroblast, CM cardiomyocyte, PC pericyte, T T cell, Endo endocardial cells, Neu neutrophil, SMC smooth muscle cell, LC lymphatic cell, B B cell, Mes mesothelial cell, NC neuron cell, Adipo adipocyte
