Fig. 2
From: Spatiotemporal transcriptomics elucidates the pathogenesis of fulminant viral myocarditis
Distinct transcriptional patterns of the hearts during FM progression. a Heatmap showing the genes with significant spatial autocorrelation grouped into different modules based on pairwise spatial correlations on cardiac tissue sections. Selected genes and their corresponding GO terms related to representative gene modules are highlighted on the right side. b The expression of module genes on cardiac tissue sections from control and CVB3-infected mice from 1 to 7 dpi. Boxplots of cardiac muscle contraction score (c), cytokine score (d), chemokine score (e) and interferon alpha score (f) of control and CVB3-infected mice from 1 to 7 dpi. g Heatmap of pathway enrichment on different spatial structures. h The pathway activation status on the typical cardiac tissue section of 7 dpi. Scale bar: 500 μm. i The activation status of typical inflammatory pathways in different types of immune cells. j The activation of pathways in the ventricle and myocarditic region at different time points
