Fig. 2 | Signal Transduction and Targeted Therapy

Fig. 2

From: A recombinant protein vaccine induces protective immunity against SARS-CoV-2 JN.1 and XBB-lineage subvariants

Fig. 2

The RBDXBB.1.5-HR vaccine induces a large number of strong RBD-specific antibody-secreting cells (ASCs). a The schematic representation of immunization and sampling schedule. NIH mice were immunized with 10 μg of RBDXBB.1.5-HR vaccine three times intramuscularly at 0, 3, and 6 weeks, the mice were sacrificed and the tissue samples were collected at 12 weeks for assays. Visual representations and quantitative assessments of RBD-specific IgG antibody secreting cells (ASCs) against XBB.1.5 (b) and JN.1 (c) variants in bone marrow and spleen tissues (n = 5 mice per group). P values in (b, c) were carried out by Two-way ANOVA followed by Sidak’s multiple comparisons test. ****P < 0.0001; ***P < 0.001; **P < 0.01; *P < 0.05

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