Fig. 7 | Signal Transduction and Targeted Therapy

Fig. 7

From: Gut dysbiosis conveys psychological stress to activate LRP5/β-catenin pathway promoting cancer stemness

Fig. 7

Working model. Psychological stress alters gut microbial community and SCFA profiles during tumor development. Administration of Akkermansia muciniphila, butyrate or high-fiber diet markedly reverses stress-caused cancer stemness and anxiety-like behavior. Butyrate transactivates ZFP36 to accelerate LRP5 mRNA decay, thereby blocking Wnt/β-catenin signaling pathway to attenuate cancer stem-like traits. Part of the elements in this figure generated from BioRender (BioRender.com)

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