Fig. 2 | Signal Transduction and Targeted Therapy

Fig. 2

From: Host FSTL1 defines the impact of stem cell therapy on liver fibrosis by potentiating the early recruitment of inflammatory macrophages

Fig. 2

Antifibrotic effects of stem cells are abrogated in Fstl1+/− mice. a Schematic illustration of hepatic fibrosis model establishment and the MSC-based treatment strategy. b–e The fibrosis degree was evaluated in Fstl1+/− (n = 5) and WT littermates (n = 5) at 4 weeks after cell infusion. b Liver sections were stained with Sirius red or Masson’s trichrome. Representative images of the staining are shown. Bars, 200 µm. c Liver fibrosis score analysis of Sirius red-stained liver sections. The fibrotic area is presented as a percentage. d The concentrations of hydroxyproline (HYP) in liver homogenates were determined. *p < 0.05, **p < 0.01, and ***p < 0.001. Statistical significance was determined by one-way ANOVA with Tukey multiple comparison test (c, d) or two-way ANOVA with Tukey multiple comparison test (e). Data are presented as the mean ± SEM and were pooled from at least three independent experiments

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