Table 1 Demographic and baseline characteristics of enrolled patients
Characteristics | N = 52 |
|---|---|
Age (year) | |
Median (range) | 54 (39–72) |
≥65, n (%) | 5 (9.6) |
Sex, male, n (%) | 25 (48.1) |
Classification, n (%) | |
T-LGLL | 45 (86.5) |
αβ type | 37 (71.2) |
γδ type | 8 (15.4) |
NK-LGLL | 7 (13.5) |
Splenomegaly, n (%) | 18 (38.3) |
Hemoglobin level (g/L) | |
Median (range) | 73 (38–139) |
≤110, n (%) | 47 (90.4) |
≤60, n (%) | 10 (19.2) |
Transfusion dependency, n (%) | 12 (23.1%) |
Platelet count (109/L) | |
Median (range) | 227 (26–539) |
≤100, n (%) | 8 (15.4) |
ANC (109/L) | |
Median (range) | 1.4 (0.3–9.2) |
<1.5, n (%) | 26 (50.0) |
<0.5, n (%) | 6 (11.5) |
LGL count (109/L), median (range) | 1.0 (0.1–12.3) |
Bone marrow cellularity | |
Hypercellular | 35 (67.3) |
Normocellular | 15 (28.8) |
Hypocellular | 2 (3.8%) |
PRCA, n (%) | 12 (23.1) |
STAT3 mutation, n (%) | 22 (56.4) |
Indications for treatment | |
Anemia | 24 (46.2) |
Neutropenia | 5 (9.6) |
Thrombocytopenia | 1 (1.9) |
Cytopenia involving two or more cell lineages | 22 (42.3) |
Coexisting autoimmune disease | 6 (11.5) |
B symptoms | 8 (15.4) |
