Fig. 3
From: Bio-barrier-adaptable biomimetic nanomedicines combined with ultrasound for enhanced cancer therapy
The homologous targeting capabilities and accumulation of MSF and MSF@CCM in vitro and in vivo. a CLSM images and (b) corresponding mean green fluorescence intensity of MSF@CCM incubated with (i) HUVEC, (ii) NIH-3T3, (iii) SCC, (iv) A549, (v) MDA-MB-231 and (vi) 4T1 cells. Scale bar = 25 μm. c CLSM images and (d) corresponding mean green fluorescence intensity of MSF and MSF@CCM incubated with RAW 264.7. Scale bar = 50 μm. e Tumor accumulation (based on Fe) of MSF and MSF@CCM in the 4T1 tumor-bearing mice after i.v. injection at different times. f Prussian blue staining of tumor after i.v. injection 4 h of MSF and MSF@CCM. Scale bar = 100 μm. Data are presented as mean ± SD (n = 3). One-way ANOVA with Tukey's multiple comparison was used to calculate statistical differences in (b, d and e)
