Fig. 7

MSF/MSF@CCM-mediated cancer therapy in vivo. a Schematic illustration of MSF/MSF@CCM induced tumor suppression. b Tumor volume of mice with different treatments. c Photographs of isolated tumors in different groups. Scale bar = 1 cm. d Tumor volume of mice with different groups. e Relative tumor weight of different groups at day 14. f Curves of mice body weight with different treatments. g H&E-stained and (h) TUNEL staining of the tumors after different treatments. i Fluorescence images of tumor slices collected after treatment for 4 h and stained with DCFH-DA. j Immunofluorescence images of GPX4 expression in tumor tissues after different treatments (red: GPX4, blue: nuclei). Scale bar = 100 μm. US: 1.0 MHz, 1.5 W cm⁻², 5 min, 50% duty cycle. Data are presented as mean ± SD (n = 5). One-way ANOVA with Tukey’s multiple comparison was used to calculate statistical differences in (b) and (e)