Fig. 3 | Signal Transduction and Targeted Therapy

Fig. 3

From: Myeloid but not hepatocytic CD38 is a key driver for hepatic ischemia/reperfusion injury

Fig. 3

Myeloid CD38 deficiency reduced hepatic ischemia-reperfusion-triggered inflammation. a–c The mRNA expressions of IL1B, TNF-α, iNOS, IL-10, ARG1, TGF-β and PPARγ were analyzed by QPCR in CD38MKO and CD38fl/fl mice after HIRI. d The expressions and the quantitative analysis of PPARγ were detected by Western blot in liver tissues of CD38MKO and CD38fl/fl mice after HIRI. e MDA contents were measured in liver tissues of CD38LKO and CD38fl/fl mice after HIRI. f The mRNA expressions of TNF-α and IL1B were determined by QPCR in liver tissues of CD38LKO and CD38fl/fl mice after HIRI. Data are shown as means ± SEM, *p < 0.05, **p < 0.01 and ***p < 0.001, n = 3 ~ 9 per group

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