Fig. 6

Global and myeloid deletion of CD38 upregulated SIRT1-p53 signaling pathway. The expressions and the quantitative analysis of SIRT1 (a, b), SIRT3 (a, b), p53 (c, d), and AC-p53 (c, d) were determined by Western blot in liver tissues from CD38^KO, CD38^MKO, and CD38^fl/fl mice after HIRI. Data are shown as means ± SEM, *p < 0.05, **p < 0.01 and ***p < 0.001, n = 3 per group