Fig. 12
From: Advances in molecular pathology and therapy of non-small cell lung cancer
Established or developing strategies to overcome drug resistance in NSCLC. This diagram categorizes treatment drugs and strategies to facilitate logical understanding, though it may not be entirely accurate. A single treatment can overcome resistance through multiple mechanisms, and conversely, a single resistance mechanism may require multiple drugs for optimal combination therapy. Future developments should focus on combining multiple treatment regimens, particularly in immunotherapy, to overcome resistance. However, determining how to combine these treatments with other therapeutic approaches not shown in the diagram, such as surgery, radiotherapy, and local ablation, remains a challenge. It is important to note that even if some drug effects are not highly pronounced, if side effects are minimal, the cumulative effect can still be considerable. ICD includes apoptosis (in some cases), necroptosis, ferroptosis, and pyroptosis
