Fig. 2 | Signal Transduction and Targeted Therapy

Fig. 2

From: Clinical investigation on nebulized human umbilical cord MSC-derived extracellular vesicles for pulmonary fibrosis treatment

Fig. 2

RNA contents of hUCMSC-EVs. a A composition analysis for the common non-coding and coding RNAs. b The pie chart shows the top 20 miRNAs, which collectively account for 68% of the total miRNAs present in hUCMSC-EVs. c An analysis of prototypic sequences representing repetitive sequence. d Total reads of the top 37 miRNAs are shown. All miRNAs were normalized to positive and negative controls. e An enrichment map of biological processes targeted by the top 37 miRNAs in hUCMSC-EVs. Nodes represent the individual genes of significantly enriched biological processes and the miRNAs which target them, connected by the edges. Genes related to the biological processes are shown as small red circles, miRNA genes are shown in blue circles. miRNAs targeting similar gene clusters are located in close proximity to one another. Each color line represents a biological process. f Enriched biological processes and g enriched KEGG pathways targeted by the miRNAs

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