Fig. 1 | Signal Transduction and Targeted Therapy

Fig. 1

From: CAR-T cell therapy for cancer: current challenges and future directions

Fig. 1

Structure of CARs. First-generation CARs consist of a ligand or scFv ectodomain and a CD3ζ TCR-type intracellular signal. Second-generation CARs contain a scFv extracellular domain and a co-stimulatory domain, 4-1BB or CD28. Third-generation CARs contain two co-stimulatory domains (usually 4-1BB and CD28). Fourth-generation CARs (TRUCKs) contain a domain encoding a specific cytokine or signal blocker/inducer. Fifth-generation CARs contain three synergistic co-stimulatory signals. This figure was created using Biorender.com

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