Fig. 9
From: CAR-T cell therapy for cancer: current challenges and future directions
AML BM niche with intrinsic and extrinsic features (a) and future strategies to modulate tumor microenvironment (b). Among the promising strategies for modulating the bone marrow microenvironment, TRUCKs (1), the addition of exogenous cytokines to boost ex-vivo expansion (2), the use of gamma-delta T cell-based products (3), and the combination with checkpoint inhibitors (4) are especially noteworthy. Figure created with Biorender.com
