Fig. 1 | Signal Transduction and Targeted Therapy

Fig. 1

From: Dual ENPP1/ATM depletion blunts DNA damage repair boosting radioimmune efficacy to abrogate triple-negative breast cancer

Fig. 1

CTC acquire an ENPP1+ signature displaying genome integrity and stemness traits. a Schematic of the isolation of engrafting “CTC-in” at the RTB after the intracardiac inoculation in previously orthotopically tumor resected mice (generated by BioRender). b Selected hierarchical functional GO categories based on their biological relevance related to the observed phenotype, obtained by transcriptomic analysis of gene signatures from two different independently isolated CTC-in cells derived from each ANV5 (CTC_A_B5coh) and 4T1 (CTC_T_B5coh) cell lines, compared to their respective parental cells using RNA-seq. Number of coherent genes with B > 5 appears in parenthesis for each cell line. c Hierarchical cluster of transcriptomic upregulated genes related to “Response to radiation” (Left panel) and Stemness (Right panel) GO categories obtained in two different independently isolated CTC-in cells derived from each ANV5 and 4T1 parental cell lines. d Validation by RT-qPCR of commonly regulated genes expressed in different CTC-in derivatives from ANV5 (700, 803, and 054) and 4T1 (1589, 1592, 1593 and 1600) isolated at the RTB compared to their respective parental ANV5 and 4T1 cell lines

Back to article page