Fig. 10 | Signal Transduction and Targeted Therapy

Fig. 10

From: Uncovering injury-specific proteomic signatures and neurodegenerative risks in single and repetitive traumatic brain injury

Fig. 10

Assessment of motor function deficits. The pole climbing test for motor coordination (a) and the grip strength test for muscle strength (b) were conducted to assess gross motor function. The plots display mean climbing time (±CI) across 3 timepoints 2, 7, and 30 days after injury: Sham (black, n = 10), smTBI (red, n = 10), and rmTBI (green, n = 10). At day 2 post-injury (a), the smTBI (***p < 0.001) and rmTBI (*p < 0.05) groups took more time to descend the pole in comparison to sham, whereas at day 7 the rmTBI group took more time than sham (***p < 0.001) to descend, indicating more severe motor coordination deficits. At 30 days following injury, smTBI groups displayed mild impairments compared to the sham (**p < 0.01). In the grip strength test (b), the sham group performed better than both smTBI (***p < 0.001) and rmTBI (***p < 0.001) at days 2 and 7 post-injury. No significant differences were observed at day 30 in either test (p > 0.05). Statistical comparisons by linear mixed-effects models (LMM). Error bars (±95% CI) reflect the uncertainty of the mean estimate at each time point

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