Fig. 11 | Signal Transduction and Targeted Therapy

Fig. 11

From: Uncovering injury-specific proteomic signatures and neurodegenerative risks in single and repetitive traumatic brain injury

Fig. 11

Spatial learning and memory at subacute (7 days) and chronic (30 days) stages. Sham (black, n = 10), smTBI (red, n = 10), and rmTBI (green, n = 10). a Acquisition latencies in the Morris water maze in the sub-acute (day 7) Stage group; rmTBI mice took the longest time, significantly on acquisition days 3 (***p = 0.001) and 4 (***p < 0.001); smTBI group showed significant deficits on the fourth acquisition day (*p < 0.05) compared to the sham. b Probe trial NE quadrant latency (subacute); rmTBI required more time (***p < 0.001) than sham. c Probe trial % time in NE quadrant (subacute); rmTBI spent less time (**p < 0.01) than sham. d–f Chronic stage (day 30) analogs: (d) acquisition day 3 showed smTBI > sham (p < *0.05) and rmTBI > sham (**p < 0.01); acquisition day 4 showed rmTBI > sham (**p < 0.01); e probe latency showed rmTBI > sham (*p < 0.05), and (f) % time where rmTBI < sham (*p < 0.05), and no smTBI deficits were observed. Statistical comparisons by linear mixed-effects models (LMM). Error bars (±95% CI)

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