Fig. 4 | Signal Transduction and Targeted Therapy

Fig. 4

From: Uncovering injury-specific proteomic signatures and neurodegenerative risks in single and repetitive traumatic brain injury

Fig. 4

Analysis of differentially expressed proteins (DEPs) overlaps across time. a Barplot showing the intersections between 48 h and 1 week time points for the different hit conditions across tissues. For each condition: green color represents genes that are uniquely deregulated at 48 h compared to SHAM; purple color represents genes that are uniquely deregulated at 1 week compared to SHAM; while orange corresponds to genes that are shared between 48 h and 1 week time points. b, c Bubble plots showing enriched GO biological process (BP) terms for various conditions organized by time. Columns represent conditions for which GO terms are either enriched for DEPs that are unique to 48 h (left), 1 week (right) or shared between both time points (middle). Bubble size and color reflect odd-ration and gene number of genes, respectively. Only the terms with an adjusted p-value less than 0.05 in at least one condition are displayed. Hippo: hippocampus; ipsi: ipsilateral; contra: contralateral. More details can be found in Supplementary Tables 5 and 6

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