Fig. 7

Weighted gene co-expression network analysis (WGCNA). a Topology overlap matrix displaying 10 modules that are shown with distinct colors. The gray color corresponds to a background module containing all proteins which were not associated with any other module. b Heatmap illustrating the module eigengenes (MEs) presenting the 9 modules of interconnected proteins. For every module, the eigengene corresponds to the first principal component (PC1) obtained from the PCA performed on the expression matrix of the associated genes. Hierarchical clustering for rows and columns was done using Euclidean distance with average linkage. Columns are annotated by tissues and experimental groups. Heatmap color is proportional to eigengene value (More details can be found in Supplementary Table 10)