Fig. 2 | Signal Transduction and Targeted Therapy

Fig. 2

From: Transferrin receptor 1 nuclear translocation facilitates tumor progression via p53-mediated chromatin interactions and genome-wide alterations

Fig. 2

Proteomic data reveal the interaction between TfR1 and p53 in the nucleus. a The top-ranking proteins identified by mass spectrometry. p53 was highlighted in orange. b, c Co-IP analysis of the interaction between TfR1 and p53 in the nuclei of HCT-116 cells (b), HT-29 cells, and MDA-MB-231 cells (c). d Measurement of TfR1 binding to p53 with single-cycle kinetics using BIAcore. e Co-IP was used to detect the association of TfR1 with p53 in the nucleus of HCT-116 xenograft tumor tissues. Lamin B1 was used as a loading control

Back to article page